dantrolene sodium
dantrolene sodium
CAS: 14663-23-1
Molecular Formula: C14H11N4NaO5
dantrolene sodium - Names and Identifiers
dantrolene sodium - Physico-chemical Properties
| Molecular Formula | C14H11N4NaO5 |
| Molar Mass | 338.25 |
| Boling Point | 85℃ 4mm |
| Solubility | Soluble in DMSO (up to 3 mg/ml) or in a 1 |
| Appearance | Orange solid |
| Color | Orange |
| Merck | 14,2816 |
| Storage Condition | Store at RT |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month. |
| Use | Skeletal muscle relaxants. |
dantrolene sodium - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | MU3875000 |
dantrolene sodium - Reference Information
| overview | dantraline sodium is a muscle relaxant that directly possesses skeletal muscle. Its main site of action is the release of calcium ions from the vesicular plasma network of skeletal muscle to weaken muscle contraction. Dantralin sodium is different from general muscle relaxants. Its unique mechanism is to directly use it in skeletal muscle. It inhibits muscle contraction by inhibiting the release of calcium ions from the sarcoplasmic reticulum, thus improving the patient's motor skills and increasing the active and passive joints The range of activity can reduce the symptoms related to the patient's difficulty in movement and promote the recovery of function. It is used for spastic hypertonia left by upper motor neuron injury caused by various reasons, such as stroke, brain injury, spinal cord injury, cerebral palsy, multiple cerebrovascular sclerosis, etc. It can also be used for emergency treatment and prevention of malignant hyperthermia and malignant syndrome caused by various reasons. Studies have shown that the therapeutic efficiency of Dantralin sodium for muscle spasm caused by cerebral palsy is 96.77%, and the total effective rate is 100%. Among them, the total effective rate of reducing muscle tension is 87.10%, the total effective rate of reducing tendon reflex is 61.29%, and the total effective rate of reducing myoclonus is 83.8%. In addition, Dantralin sodium can also be used for skeletal muscle tonic contraction caused by other non-injury factors, such as malignant hyperthermia and malignant syndrome. These diseases are mostly acute and have poor oral effects. |
| domestic dantralin sodium approved | the approval of domestic injection type "dantralin sodium" not only marks the improvement of the research and development technology level of China's pharmaceutical enterprises, but also reflects the national emphasis on the development of anesthesia discipline and the development of narcotic drugs. The approval of dantralin sodium reduces the risk of death of patients, reduces medical disputes of anesthesiologists, and improves the self-confidence of anesthesiologists. |
| pharmacological effects | dantralin sodium is a muscle relaxant that directly acts on skeletal muscle. Its main site of action is the sarcoplasmic reticulum of skeletal muscle, which reduces muscle contraction by inhibiting the release of calcium ions from the sarcoplasmic reticulum. |
| pharmacokinetics | slow and incomplete absorption after oral administration. After liver metabolism, its metabolites are excreted from the kidney. The half-life (t1/2) of adults after oral administration of 100mg is 8.7 hours on average. The time and degree of skeletal muscle relaxation are related to the dosage. |
| clinical application and indications | for spastic hypertonia left by upper motor neuron injury caused by various reasons, such as stroke, brain trauma, spinal cord injury, cerebral palsy, multiple cerebrovascular sclerosis, etc. |
| adverse reactions | muscle weakness, lethargy, dizziness, fatigue and discomfort, diarrhea may occur. rare cases include tachycardia, unstable blood pressure, pleural effusion, pericarditis, hematuria, urination disorders, etc. if necessary, drug withdrawal shall be required. Long-term use may cause liver and kidney damage. |
| taboo | 1. those who are allergic to this product. 2. Liver and kidney dysfunction. 3. Functional spasticity. 4. Joint disease and muscle spasm after trauma. women over 5.35 years old and on estrogen. |
| use | skeletal muscle relaxant. |
Last Update：2024-04-10 22:29:15
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View History
dantrolene sodium
Acetic acid, (2-methylphenoxy)- (9CI)
Non-flocculating Green G
Kayalon Polyester Red BL-E
Finerenone Impurity 51
Barium molybdate
AFB STAIN
SUBEROYL DICHLORIDE
C.I. 11115
Butyltin oxide
Acetic acid, (2-methylphenoxy)- (9CI)
Non-flocculating Green G
Kayalon Polyester Red BL-E
Finerenone Impurity 51
Barium molybdate
AFB STAIN
SUBEROYL DICHLORIDE
C.I. 11115
Butyltin oxide